Sepsis and other acute injuries such as severe trauma, extensive burns, or major surgeries,
are usually followed by a period of marked immunosuppression. In particular, while …

The often fatal sepsis syndrome is characterized by the systemic release of inflammatory
mediators, which is regulated and counterbalanced by the coordinated expression of anti …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe
infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been …

Sepsis and multiple organ failure continue to be significant problems among trauma, burn,
and the critically ill patient population. Thus, a number of laboratories have focused on …

Sepsis is a syndrome of shock and dysfunction of multiple vital organs that is caused by an
uncontrolled immune response to infection and has a high mortality rate. There are no …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …

Systemic inflammatory response to severe injury or sepsis is the result of virtually
uninhibited proinflammatory cytokine activities. Despite remarkable advances in delineating …

Some labile cell types whose numbers are normally controlled through programmed cell
death are subject to markedly increased destruction during some severe infections …

Recent efforts have focused on immunoadjuvant therapies for sepsis. The host inflammatory
response consequent to initial exposure to pathogens is often followed by anti‐inflammatory …