Apoptosis is of pivotal importance in the pathogenesis of sepsis. Depending on the cell type
involved and the time point of the disease process, apoptosis may be linked to either a good …

Despite multiple trials of potential therapies for sepsis, no strategies have yet been
persistently shown to have beneficial effects on outcomes. The main reason for the …

The immune system plays a dual role in the pathogenesis of sepsis and organ failure,
intended for hast defense but also possessing significant cytodestructive capacity, As the …

Sepsis induces extensive apoptosis of lymphocytes, which may be responsible for the
profound immune suppression of the disorder. Two potential pathways of sepsis-induced …

Despite often knowing the aetiology of sepsis and its clinical course there has not been the
anticipated advances in treatment strategies. Cytokines are influential mediators of …

Sepsis is a common clinical problem that is responsible for an increasing number of deaths.
Many new therapies for severe sepsis have been developed but few have shown benefit in …

Septic shock has traditionally been viewed as an excessive systemic inflammatory reaction
to invasive microbial pathogens, yet efforts to improve outcome in septic patients with …

Sepsis is the leading cause of death among critically ill patients in intensive care units, and
treatment options are limited. Therapies developed against the proinflammatory stage have …

T-cell apoptosis during septic shock (SS) has been associated with deleterious outcome, but
the mechanisms of apoptosis are not well understood. As T-cells are not infected in bacterial …

An excessive inflammatory response accompanies the initial stages of severe infection and
appears to contribute to associated organ system failure and death [1ą3]. A number of …