Considering immunomodulatory therapies in the septic patient: should apoptosis be a potential therapeutic target?
A Oberholzer, C Oberholzer, RM Minter, LL Moldawer - Immunology Letters, 2001 - Elsevier
Treatment of sepsis and septic shock remains a clinical conundrum. Recent prospective
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …
trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical …
Apoptosis in sepsis: a new target for therapeutic exploration
C Oberholzer, A Oberholzer, M Clare-Salzler… - The FASEB …, 2001 - Wiley Online Library
The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …
prospective trials with biological response modifiers aimed at the inflammatory response …
Role of programmed cell death in the immunopathogenesis of sepsis
M Perl, CS Chung, R Swan, A Ayala - Drug Discovery Today: Disease …, 2007 - Elsevier
Apoptosis is an important mechanism during the immunopathogenesis of sepsis. Early
programmed cell death of lymphocytes substantially impairs innate and adaptive immunity …
programmed cell death of lymphocytes substantially impairs innate and adaptive immunity …
Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis
C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …
response to infection that leads to uncontrolled inflammatory response followed by …
Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis
A Ayala, DE Wesche‐Soldato, M Perl… - Sepsis: New Insights …, 2006 - Wiley Online Library
Over time it has become clear that, much like other organ systems, the function and
responsiveness of the immune system is impaired during the course of sepsis and that this is …
responsiveness of the immune system is impaired during the course of sepsis and that this is …
Role of apoptotic cell death in sepsis
RS Hotchkiss, KW Tinsley, IE Karl - Scandinavian journal of …, 2003 - Taylor & Francis
Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …
[HTML][HTML] Simultaneous activation of apoptosis and inflammation in pathogenesis of septic shock: a hypothesis
VD Joshi, DV Kalvakolanu, AS Cross - FEBS letters, 2003 - Elsevier
Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …
result from uncontrolled inflammatory responses to microbial infection and/or components …
Apoptosis in sepsis
R Mahidhara, TR Billiar - Critical care medicine, 2000 - journals.lww.com
Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …
infection. Previous models have focused on the mechanisms which upregulate and sustain …
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
RS Hotchkiss, KW Tinsley, PE Swanson… - The Journal of …, 2001 - journals.aai.org
Patients with sepsis have impaired host defenses that contribute to the lethality of the
disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the …
disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the …
Prevention of lymphocyte apoptosis—a potential treatment of sepsis?
RS Hotchkiss, CM Coopersmith… - Clinical Infectious …, 2005 - academic.oup.com
Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …
morbidity and mortality in neonatal and medical intensive care units. The Centers for …
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