p53-dependent and-independent pathways of apoptotic cell death in sepsis
RS Hotchkiss, KW Tinsley, JJ Hui… - The Journal of …, 2000 - journals.aai.org
Sepsis induces extensive apoptosis of lymphocytes, which may be responsible for the
profound immune suppression of the disorder. Two potential pathways of sepsis-induced …
profound immune suppression of the disorder. Two potential pathways of sepsis-induced …
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
RS Hotchkiss, G Monneret, D Payen - The Lancet infectious diseases, 2013 - thelancet.com
Failures of highly touted trials have caused experts to call for re-evaluation of the current
approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy …
approach toward sepsis. New research has revealed key pathogenic mechanisms; autopsy …
The immune system: relation to sepsis and multiple organ failure
The immune system plays a dual role in the pathogenesis of sepsis and organ failure,
intended for hast defense but also possessing significant cytodestructive capacity, As the …
intended for hast defense but also possessing significant cytodestructive capacity, As the …
Targeting cytokines as a treatment for patients with sepsis: A lost cause or a strategy still worthy of pursuit?
KA Brown, GA Brown, SM Lewis, R Beale… - International …, 2016 - Elsevier
Despite often knowing the aetiology of sepsis and its clinical course there has not been the
anticipated advances in treatment strategies. Cytokines are influential mediators of …
anticipated advances in treatment strategies. Cytokines are influential mediators of …
New therapies for sepsis
A Cunnington, S Nadel - Current topics in medicinal chemistry, 2008 - ingentaconnect.com
Sepsis is a common clinical problem that is responsible for an increasing number of deaths.
Many new therapies for severe sepsis have been developed but few have shown benefit in …
Many new therapies for severe sepsis have been developed but few have shown benefit in …
[HTML][HTML] Immunotherapy for sepsis: a new approach against an ancient foe
RS Hotchkiss, SM Opal - The New England journal of medicine, 2010 - ncbi.nlm.nih.gov
Septic shock has traditionally been viewed as an excessive systemic inflammatory reaction
to invasive microbial pathogens, yet efforts to improve outcome in septic patients with …
to invasive microbial pathogens, yet efforts to improve outcome in septic patients with …
The new normal: immunomodulatory agents against sepsis immune suppression
NA Hutchins, J Unsinger, RS Hotchkiss… - Trends in molecular …, 2014 - cell.com
Sepsis is the leading cause of death among critically ill patients in intensive care units, and
treatment options are limited. Therapies developed against the proinflammatory stage have …
treatment options are limited. Therapies developed against the proinflammatory stage have …
Enhanced T-cell apoptosis in human septic shock is associated with alteration of the costimulatory pathway
PM Roger, H Hyvernat, JP Breittmayer… - European journal of …, 2009 - Springer
T-cell apoptosis during septic shock (SS) has been associated with deleterious outcome, but
the mechanisms of apoptosis are not well understood. As T-cells are not infected in bacterial …
the mechanisms of apoptosis are not well understood. As T-cells are not infected in bacterial …
Why immunomodulatory therapies have not worked in sepsis
E Abraham - Intensive care medicine, 1999 - search.proquest.com
An excessive inflammatory response accompanies the initial stages of severe infection and
appears to contribute to associated organ system failure and death [1ą3]. A number of …
appears to contribute to associated organ system failure and death [1ą3]. A number of …
Changes in immune function and immunomodulatory treatments of septic patients
Z Xu, A Liu, L Yang, B Zhang, F Zheng, J Zhang… - Clinical …, 2022 - Elsevier
Although the mortality rate of sepsis decreases annually, sepsis is still one of the most
common causes of death in hospitals. Specific treatments have not been researched yet …
common causes of death in hospitals. Specific treatments have not been researched yet …