An excessive inflammatory response accompanies the initial stages of severe infection and
appears to contribute to associated organ system failure and death [1ą3]. A number of …

Although the mortality rate of sepsis decreases annually, sepsis is still one of the most
common causes of death in hospitals. Specific treatments have not been researched yet …

Sepsis is a syndrome related to severe infections. It is defined as the systemic host response
to microorganisms in previously sterile tissues and is characterized by end-organ …

Sepsis is amongst the world's biggest public health problems with more than 20 million
cases worldwide and a high morbidity rate of up to 50%. Despite advances in modern …

Sepsis is now understood to affect a variety of changes in the host, chief among them being
alterations in immune system function. Proper immune function involves a competent …

Severe infection can lead to sepsis. In sepsis, the host mounts an inappropriately large
inflammatory response in an attempt to clear the invading pathogen. This sustained high …

Sepsis is the most frequent cause of death in noncoronary intensive care units. In the past
10 years, progress has been made in the early identification of septic patients and their …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Sepsis is a life-threatening disease caused by a systemic infection that triggers a
dysregulated immune response. Sepsis is an important cause of death in intensive care …

Systemic immune dysregulation is generally acknowledged to be the fundamental molecular
mechanism that underlies the pathophysiology of severe sepsis and septic shock. In the …