Apoptosis, as a biological phenomenon, is readily identifiable by several characteristic
features. It characteristically affects scattered single cells, not groups of contiguous cells as …

Induction of apoptosis in immune cells is a crucial mechanism used by the body to produce
immune resolution. The homeostatic mechanisms employed are currently being identified …

Sepsis is a clinical syndrome that results from a systemic host response to an infection. The
outcome of sepsis is poor, and mortality rates are as high as 30–40%. Sepsis is associated …

Sepsis is a life-threatening disease caused by a systemic infection that triggers a
dysregulated immune response. Sepsis is an important cause of death in intensive care …

The sepsis syndrome is characterized by the acute release of a variety of inflammatory
mediators, which often result in detrimental effects to the host. The release of these …

Through improvements in supportive care measures over the last few decades, such as
those guidelines based on the 'Surviving Sepsis Campaign'and early goal-directed therapy …

While antibiotics address the root cause of sepsis—that of pathogen infection—they fail to
provide an adequate cure for the condition. Currently, 30% to 50% of septic patients die, and …

Sepsis induces extensive apoptosis in T and B cells suggesting that the loss of immune
effector cells could be one explanation for the profound immunosuppression observed in …

Human sepsis is characterized by a profound stimulation of the immune system. This results
in the activation of multiple biological cascades, including inflammation (cytokines …

Sepsis continues to cause significant morbidity and mortality in critically ill patients. Studies
of patients and animal models have revealed that changes in the immune response during …