Conspectus Drug-resistant bacterial infections pose an imminent and growing threat to
public health. The discovery and development of new antibiotics of novel chemical class and …

Antibiotics are essential weapons in our fight against infectious disease, yet the
consequences of broad-spectrum antibiotic use on microbiome stability and pathogen …

While genetic perturbation has been the conventional route to probing bacterial systems,
small molecules are showing great promise as probes for cellular complexity. Indeed …

Advances in sequencing technology have provided an unprecedented view of bacterial
diversity, along with a daunting number of novel genes. Within this new reality lies the …

Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

Future Microbiol.(2011) 6 (6) 604 future science group use of systems biology to kill. Real
antibacterials work within the cellular context by corrupting metabolic and information …

Antibiotics are essential for both treating and preventing infectious diseases. Paradoxically,
despite their importance as pillars of modern medicine, we are in danger of losing antibiotics …

The emergence of antibiotic-resistant pathogens, multiple drug-resistance, and extremely
drug-resistant strains demonstrates the need for improved strategies to discover new drug …

The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …

Antibiotics are arguably the most successful medicine on the planet, but the one under huge
threat from antibiotic resistance in the face of diminishing new antimicrobial discovery efforts …