We show that convergent transcription induces transcriptional gene silencing (TGS) in trans
for both fission yeast and mammalian cells. This method has advantages over existing …

Histone modifications influence gene expression in complex ways. The RNA interference
(RNAi) machinery can repress transcription by recruiting histone-modifying enzymes to …

Post‐translational modifications of histones are critical not only for local regulation of gene
expression, but also for higher‐order structure of the chromosome and genome organization …

Plants and fission yeast exhibit a wealth of epigenetic phenomena, including transposon
regulation, heterochromatic silencing, and gene imprinting. They provide excellent model …

Specific gene silencing has been demonstrated in a number of organisms by the
introduction of antisense RNA. Mutagenesis of host-encoded factors has begun to unravel …

In the fission yeast Schizosaccharomyces pombe, the RNAi pathway plays an important role
in the formation and maintenance of heterochromatin. Heterochromatin, or silent chromatin …

Transcriptional silencing is a phenomenon in which the transcription of a gene by RNA
polymerase II or III is repressed or not, dependent only on the gene's chromosomal location …

The compressed nature of genes in yeast requires that transcription units be well defined to
prevent read-though transcription from one gene into an adjacent gene. Failure to terminate …

Multiple mechanisms have been proposed for gene silencing in Saccharomyces cerevisiae,
ranging from steric occlusion of DNA binding proteins from their recognition sequences in …

RNA interference is a conserved mechanism by which double-stranded RNA is processed
into short interfering RNAs (siRNAs) that can trigger both post-transcriptional and …