It has been over a decade since the first observation that small non-coding RNAs can
functionally modulate epigenetic states in human cells to achieve functional transcriptional …

Gene silencing is a general term describing epigenetic processes of gene regulation. The
term gene silencing is generally used to describe the'switching off'of a gene by a mechanism …

Transcriptional silencing in Saccharomyces requires specific nucleosome modifications
promoted in part by a complex of Sir proteins that binds to the modified nucleosomes …

Small interfering RNAs (siRNAs) act through RNA interference (RNAi) pathways to silence
gene expression either at the transcriptional or post-transcriptional level. Here, we review …

In most eukaryotes, histone and DNA modifications are responsible for the silencing of
genes integrated in heterochromatic sequences, as well as the silencing of pericentromeric …

Transcriptional repression of the silent mating-type loci in Saccharomyces cerevisiae
requires a cell cycle–dependent establishment step that is commonly assumed to involve …

RNA interference (RNAi) is a conserved mechanism in which small interfering RNAs
(siRNAs) guide the degradation of cognate RNAs, but also promote heterochromatin …

Imagine being able to knock out your favourite gene with only a day's work. Not just in one
model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of …

Transcriptional silencing in Saccharomyces cerevisiaeoccurs at several genetic loci,
including the ribosomal DNA (rDNA). Silencing at telomeres (telomere position effect [TPE]) …

Transcriptional silencing is the most well-studied epigenetic phenomenon in yeast. In
Saccharomyces cerevisiae, silencing has recently been found at previously unidentified loci …