Codon usage bias is a well recognized phenomenon but the relative influence of its major
causes: G+ C content, mutational biases, and selection, are often difficult to disentangle …

Codon usage bias (CUB) is a species-specific phenomenon where some codons are used
more commonly than their synonymous partners. It helps to understand the effect of …

Genomic regions conserved during evolution are important, but they have been ignored in
conservation genetics. Managing deleterious mutations in such ultraconserved elements by …

The genetic code is necessarily degenerate with 64 possible nucleotide triplets being
translated into 20 amino acids. Eighteen out of the 20 amino acids are encoded by multiple …

Codon usage bias (CUB) has been documented across a wide range of taxa and is the
subject of numerous studies. While most explanations of CUB invoke some type of natural …

The mutational robustness of the genetic code is rarely discussed in the context of biological
diversity, such as codon usage and related factors, often considered as independent of the …

Since the genetic code is degenerate, several codons are translated to the same amino
acid. Although these triplets were historically considered to be “synonymous” and therefore …

Estimation of natural selection on protein-coding sequences is a key comparative genomics
approach for de novo prediction of lineage-specific adaptations. Selective pressure is …

Forces that influence the evolution of synonymous codon usage bias are analyzed in six
species of three basal orders of aquatic insects. The rationale behind choosing six species …

It has recently been demonstrated that human natural codon usage bias is optimized
towards a higher buffering capacity to mutations (measured as the tendency of single point …