Mutation rate varies greatly between nucleotide sites of the human genome and depends
both on the global genomic location and the local sequence context of a site. In particular …

Different frequencies amongst codons that encode the same amino acid (ie synonymous
codons) have been observed in multiple species. Studies focused on uncovering the forces …

Evolutionary studies commonly model single nucleotide substitutions and assume that they
occur as independent draws from a unique probability distribution across the sequence …

Previous studies observed a higher ratio of divergences at nonsynonymous and
synonymous sites (ω= d N/d S) in species with a small population size compared to that …

The role of adaptation is a fundamental question in molecular evolution. Theory predicts that
species with large effective population sizes should undergo a higher rate of adaptive …

Eyre-WALKER (1997) discusses some problems of infemng evolutionary processes when
mutation rates and biases vary over time. The letter specifically addresses statistical “tests of …

Through an analysis of polymorphism within and divergence between species, we can hope
to learn about the distribution of selective effects of mutations in the genome, changes in the …

Inferring the selective forces that orthologous genes underwent across different lineages can
help us understand the evolutionary processes that have shaped their extant diversity and …

Selection at the DNA level is usually detected by analysing substitution rates from multiple-
species comparisons. It has been suggested that measures of genetic robustness at the …

Background Codon usage bias (CUB), the uneven use of synonymous codons, is a
ubiquitous observation in virtually all organisms examined. The pattern of codon usage is …