Elevated levels of genetic drift are hypothesized to be a dominant factor that influences
genome size evolution across all life-forms. However, increased levels of drift appear to be …

Motivation: Comparing the genomes from closely related species provides a powerful tool to
identify functional elements in a reference genome. Many methods have been developed to …

Codon bias study in an organism gains significance in understanding the molecular
mechanism as well as the functional conservation of gene expression during the course of …

In large part, the relevance of genetics to conservation rests on the premise that neutral
marker variation in populations reflects levels of detrimental and adaptive genetic variation …

Codon usage bias (CUB) results from the complex interplay between translational selection
and mutational biases. Current methods for CUB analysis apply heuristics to integrate both …

Slightly deleterious mutations are expected to fix at relatively higher rates in small
populations than in large populations. Support for this prediction of the nearly-neutral theory …

Most previous studies of the evolution of codon usage bias (CUB) and intronic GC content
(iGC) in Drosophila melanogaster were based on between-species comparisons, reflecting …

A low ratio of nonsynonymous and synonymous substitution rates (dN/dS) at a codon is an
indicator of functional constraint caused by purifying selection. Intuitively, the functional …

Sequences for multiple protein-coding genes are now commonly available from several,
often closely related species. These data sets offer intriguing opportunities to test …

Codon usage is the selective and nonrandom use of synonymous codons to encode amino
acids in genes for proteins. The analysis of codon usage may improve the understanding of …