Obesity is a complex metabolic disorder associated with the development of non-
communicable diseases such as cirrhosis, non-alcoholic fatty liver disease, and type 2 …

The current dogma is that obesity-associated hepatic inflammation is due to increased
Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently …

The increasing prevalence of obesity is accompanied by a rising incidence in metabolic
syndrome and related pathologies such as non-alcoholic fatty liver disease. Macrophages …

Low-grade inflammation in the obese AT (AT) and the liver is a critical player in the
development of obesity-related metabolic dysregulation, including insulin resistance, type 2 …

Recruited adipose tissue macrophages contribute to chronic and low-grade inflammation
causing insulin resistance in obesity. Similarly, we hypothesized here that Kupffer cells, the …

Overnutrition and a sedentary lifestyle have resulted in the expansion of human obesity and
associated metabolic complications. Nonalcoholic fatty liver disease has become the most …

OBJECTIVE Increased activity of the innate immune system has been implicated in the
pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 …

Obesity is causally linked to a chronic state of “low-grade” inflammation in adipose tissue.
Prolonged, unremitting inflammation in this tissue has a direct impact on insulin-sensitive …

While adipose tissue-associated macrophages contribute to development of chronic
inflammation and insulin resistance of obesity, little is known about the role of hepatic …

Fatty liver disease, characterized by excessive inflammation and lipid deposition, is
becoming one of the most prevalent liver metabolic diseases worldwide owing to the …