Identifying amyloid pathology–related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study

YY Leung, JB Toledo, A Nefedov… - Alzheimer's & …, 2015 - Wiley Online Library
Introduction The dynamic range of cerebrospinal fluid (CSF) amyloid β (Aβ1–42)
measurement does not parallel to cognitive changes in Alzheimer's disease (AD) and …

Cerebrospinal fluid biomarkers for Alzheimer's disease: diagnostic performance in a homogeneous mono-center population

P Johansson, N Mattsson, O Hansson… - Journal of …, 2011 - content.iospress.com
The cerebrospinal fluid (CSF) biomarkers amyloid-ß (Aß) 1-42, T-tau, and P-tau have good
diagnostic accuracy for clinically diagnosed Alzheimer's disease (AD). However, in multi …

[HTML][HTML] Longitudinal cerebrospinal fluid biomarker measurements in preclinical sporadic Alzheimer's disease: A prospective 9-year study

E Stomrud, L Minthon, H Zetterberg, K Blennow… - Alzheimer's & Dementia …, 2015 - Elsevier
Introduction Ascertainment of the pattern and temporal change of biomarkers in preclinical
(asymptomatic) sporadic Alzheimer's disease (AD) will increase knowledge about early …

A protein panel in cerebrospinal fluid for diagnostic and predictive assessment of Alzheimer's disease

R Haque, CM Watson, J Liu, EK Carter… - Science translational …, 2023 - science.org
Alzheimer's disease (AD) is a neurodegenerative disease with heterogenous
pathophysiological changes that develop years before the onset of clinical symptoms. These …

Cerebrospinal fluid biomarkers distinguish postmortem-confirmed Alzheimer's disease from other dementias and healthy controls in the OPTIMA cohort

JL Seeburger, DJ Holder, M Combrinck… - Journal of …, 2015 - content.iospress.com
Cerebrospinal fluid (CSF) amyloid-β (Aβ) and tau have been studied as markers of
Alzheimer's disease (AD). Combined Aβ 42 and t-tau distinguishes AD from healthy controls …

Concordance between cerebrospinal fluid biomarkers with Alzheimer's disease pathology between three independent assay platforms

JD Doecke, A Rembach… - Journal of …, 2017 - journals.sagepub.com
Background: To enhance the accuracy of clinical diagnosis for Alzheimer's disease (AD), pre-
mortem biomarkers have become increasingly important for diagnosis and for participant …

Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease

AH Simonsen, J McGuire, VN Podust, H Davies… - Neurobiology of …, 2008 - Elsevier
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate
symptomatic treatment with currently approved drugs and will be of even greater importance …

Predicting progression and cognitive decline in amyloid-positive patients with Alzheimer's disease

HV Dansson, L Stempfle, H Egilsdóttir… - Alzheimer's Research & …, 2021 - Springer
Abstract Background In Alzheimer's disease, amyloid-β (A β) peptides aggregate in the
lowering CSF amyloid levels-a key pathological hallmark of the disease. However, lowered …

Comparison of commonly measured plasma and cerebrospinal fluid proteins and their significance for the characterization of cognitive impairment status

H Rehman, TFA Ang, Q Tao… - Journal of …, 2024 - journals.sagepub.com
Background: Although cerebrospinal fluid (CSF) amyloid-β42 peptide (Aβ42) and
phosphorylated tau (p-tau) and blood p-tau are valuable for differential diagnosis of …

CSF‐Targeted Proteomics Indicate Amyloid‐Beta Ratios in Patients with Alzheimer's Dementia Spectrum

M Behzad, N Zirak, GH Madani… - International Journal …, 2023 - Wiley Online Library
Background. According to recent studies, amyloid‐β (Aβ) isoforms as cerebrospinal fluid
(CSF) biomarkers have remarkable predictive value for cognitive decline in the early stages …