Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) functions at the center of cellular stress
and sways the immune system at several key points, thus modulates inflammatory diseases …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a DNA nick-sensor enzyme that
functions at the center of cellular stress response and affects the immune system at several …

Poly (ADP-ribose) polymerase-1 (PARP-1) is involved in DNA repair, but its overactivation
can induce cell death. Our aim was to investigate the role of PARP-1 in activation of …

Neuro-inflammation and dysfunction of blood–brain barrier play an important role in the
occurrence, development, and neuronal degeneration of Parkinson's disease (PD). Studies …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in DNA repair processes
during oxidative/genotoxic stress, in regulation of transcription factors and in cell death …

A bstract Our previous data demonstrated that systemic inflammation evoked by
intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg bw) induces morphological and …

In the presence of genotoxic stress poly (ADP‐ribose) polymerase‐1 (PARP‐1) leads to
NAD+ and ATP depletion, participating in the pathogenesis of several disorders including …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in DNA repair,
replication and cell cycle. However, its overactivation leads to nicotinamide adenine …

Background Considerable evidence has shown that neuroinflammation and oxidative stress
play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) …

Oxidative stress has been shown to be implicated in the pathogenesis of central nervous
system injuries such as cerebral ischemia and trauma, and chronic neurodegenerative …