Cytokine profiles of cells extracted from humans with periodontal diseases

E Gemmell, GJ Seymour - Journal of dental research, 1998 - journals.sagepub.com
FACS analysis was used to determine the percent interferon (IFN)-gamma-, interleukin (IL)-4-
, IL-10-, and CD30-positive T-cells extracted from adult periodontitis (AP) and …

Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease

K Yamazaki, T Nakajima, K Hara - Clinical & Experimental …, 1995 - Wiley Online Library
SUMMARY IL‐2, interferon‐gamma (IFN‐γ), IL‐4 and IL‐6 producing T cells in periodontitis
and gingivitis‐affected human tissues were investigated by immunohistochemistry to clarify …

P. gingivalis-specific T-cell Lines Produce Th1 and Th2 Cytokines

E Gemmell, CL Carter, DA Grieco… - Journal of dental …, 2002 - journals.sagepub.com
Cytokines produced by T-cells in periodontal lesions may determine the nature of the
adaptive immune response. Since different antigen-presenting cells (APC) may direct the …

Phenotypical and functional analysis of T cells in periodontitis

MDA Petit, E Hovenkamp, D Hamann… - Journal of …, 2001 - Wiley Online Library
To explore aspects of cellular immune responses in the pathogenesis of periodontitis we
analyzed phenotype and function of peripheral T cells. Two groups of subjects participated …

Selected Th1 and Th2 cytokine mRNA expression by CD4+ T cells isolated from inflamed human gingival tissues

K Fujihashi, M Yamamoto, T Hiroi… - Clinical & …, 1996 - Wiley Online Library
Elevated numbers of plasma cells are associated with localized and chronically inflamed
gingiva of patients with adult periodontitis. However, only limited information is currently …

Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.

K Fujihashi, Y Kono, KW Beagley… - Journal of …, 1993 - europepmc.org
Localized and chronically-inflamed gingival tissues of adult periodontitis (AP) are generally
characterized as a hyper-responsiveness of B lineage cells where increased numbers of …

Relative proportions of T‐cell subpopulations and cytokines that mediate and regulate the adaptive immune response in patients with aggressive periodontitis

LJ Suárez, AM Ocampo, RE Dueñas… - Journal of …, 2004 - Wiley Online Library
Background: Both the virulence factors of periodontopathic bacteria and the immune
response against them have been involved in tissue destruction observed in periodontal …

Antigen‐presenting cells in human periodontal disease tissues

E Gemmell, CL Carter, DNJ Hart… - Oral microbiology …, 2002 - Wiley Online Library
T cells are present in the inflammatory infiltrates of periodontal disease lesions and require
antigen presentation by antigen‐presenting cells (APCs). While it is still not known whether …

Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing

O Takeichi, J Haber, T Kawai, DJ Smith… - Journal of dental …, 2000 - journals.sagepub.com
Periodontal disease is an infection in which destruction occurs at sites remote from the
infection, resulting in pathological pocketing. Intervening between the infection and the …

Gingival cell IL‐2 and IL‐4 in early‐onset periodontitis

SS Manhart, RA Reinhardt, JB Payne… - Journal of …, 1994 - Wiley Online Library
The purpose of this study was to compare, using cell blot analysis, the association of
gingival tissue mononuclear cells (GTMC) isolated from lesions displaying histories of early …