[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
siRNA versus miRNA as therapeutics for gene silencing
JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
RNAi-based therapeutics and novel RNA bioengineering technologies
RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …
The race of 10 synthetic RNAi-based drugs to the pharmaceutical market
R Titze-de-Almeida, C David… - Pharmaceutical …, 2017 - Springer
Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …
siRNA therapeutics: a clinical reality
PE Saw, EW Song - Science China Life Sciences, 2020 - Springer
Since the revolutionary discovery of RNA interference (RNAi), a remarkable progress has
been achieved in understanding and harnessing gene silencing mechanism; especially in …
been achieved in understanding and harnessing gene silencing mechanism; especially in …
Clinical advances of siRNA therapeutics
B Hu, Y Weng, XH Xia, X Liang… - The journal of gene …, 2019 - Wiley Online Library
Small interfering RNA (siRNA) enables efficient target gene silencing by employing a RNA
interference (RNAi) mechanism, which can compromise gene expression and regulate gene …
interference (RNAi) mechanism, which can compromise gene expression and regulate gene …
The risks of miRNA therapeutics: in a drug target perspective
S Zhang, Z Cheng, Y Wang, T Han - Drug design, development …, 2021 - Taylor & Francis
RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
were approved by the Food and Drug Administration in 2018 and 2019, respectively …
The guideline of the design and validation of MiRNA mimics
Z Wang - MicroRNA and Cancer: Methods and Protocols, 2011 - Springer
The miRNA mimic technology (miR-Mimic) is an innovative approach for gene silencing.
This approach is to generate nonnatural double-stranded miRNA-like RNA fragments. Such …
This approach is to generate nonnatural double-stranded miRNA-like RNA fragments. Such …
Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine
C Chakraborty, AR Sharma, G Sharma… - … Therapy-Nucleic Acids, 2017 - cell.com
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are
some of the most important biopharmaceuticals that are in commercial space as future …
some of the most important biopharmaceuticals that are in commercial space as future …
Clinical applications of short non-coding RNA-based therapies in the era of precision medicine
Simple Summary RNA-based drugs are an attractive approach for personalized treatment of
cancer and other diseases. This review focuses on two related classes of short non-coding …
cancer and other diseases. This review focuses on two related classes of short non-coding …