Shock, defined at a cellular level, is a condition in which oxygen delivery to the cells is not
sufficient to sustain cellular activity and support organ function. The central role of …

The ultimate goals of hemodynamic therapy in sepsis are to restore effective tissue perfusion
and to maintain cellular metabolism. Fluid resuscitation is the first step in management of …

Largely ignored throughout the history of clinical medicine, the microcirculation has recently
been recognized at the bedside as the center of several pathophysiological processes …

Retrospective data analysis of microcirculation in septic shock was conducted. Sepsis is
characterized by a severe microvascular dysfunction that persists despite fluid resuscitation …

Microcirculation is a key element in the pathophysiology of sepsis. Even if microcirculation-
targeted therapy is not yet ready for the prime time, understanding the processes implicated …

Microcirculatory dysfunction has been recently recognized as a key pathophysiologic
process in the evolution of sepsis. In the present review, we discuss fundamental aspects of …

Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that
maintaining systemic blood pressure is associated with inadequate perfusion of the …

Sepsis is a leading cause of mortality in critically ill patients. The pathophysiology of sepsis
involves a highly complex and integrated response, including the activation of various cell …

Microvascular alterations are a hallmark of sepsis and play a crucial role in its
pathophysiology. Such alterations are the result of overwhelming inflammation, which …

Mortality of critically ill patients is driven by severity of the insult, comorbidities, appropriate
treatment, and organ failure. The pathophysiological mechanisms leading to organ failure …