The transition from compensated hypertrophy to failure in spontaneously hypertensive rats
(SHR) of advanced age is associated with a marked increase in collagen, a reduction in …

Cardiovascular disease is a leading cause of death worldwide. In recent years it has
emerged that loss of myocardial cells may be a major pathogenic factor. Cell death can …

1812 FUJITA T et al. cyclase (AC) and cyclic adenosine monophosphate (cAMP). 2 PKA-
mediated phosphorylation of many calcium-handling molecules enhances ventricular wall …

Background To formally test whether the antiapoptotic protein bcl-2 would prevent
programmed cell death in cardiac muscle cells provoked by p53, a known trigger of …

Cardiac apoptosis has been considered an important contributing factor to heart failure.
Several subcellular mechanisms, including increased protein phosphatase 1 activity, have …

Background—Apoptosis may contribute to the development of heart failure, but the role of
apoptotic signaling initiated by the endoplasmic reticulum in this condition has not been well …

Background: Apoptosis may contribute to the myocardial dysfunction associated with heart
failure (HF). Activation of the p38 MAPK cascade can induce apoptosis in non‐cardiac cells …

Exercise training could potentially exert beneficial effects on the signaling events associated
with cardiac cell apoptosis. Spontaneously hypertensive rats (SHR) were trained 5 …

Objectives Cardiac apoptosis was found in ovariectomized rats without ischemia. Limited
information regarding the protective effects of 17β‐estradiol (E2) on cardiac Fas‐dependent …

Background In general, myocyte death in myocardial infarctions (MIs) is attributed to
necrosis, but recently the involvement of apoptosis has been suggested. The ratio of bcl-2 …