Obesity has traditionally been considered an independent risk factor for heart failure whose
pathophysiology is generally believed to associated with the consequence of myocyte …

Following myocardial infarction (MI), tissue repair/remodeling occurs in both the infarcted
and noninfarcted myocardium. Apoptosis has been demonstrated to play an important role …

It has been reported that programmed cell death (apoptosis) occurs during myocardial
infarction. The influence of age on programmed cell death or DNA fragmentation after …

Although the involvement of caspases in cardiomyocyte death is widely accepted [reviewed
in1], increasing experimental evidence suggests that caspase activation is not relevant for …

Correlation of cardiomyocyte apoptosis with duration of hypertension, severity of
hypertension and caspase‑3 expression in hypertensive rats was analyzed. Sixty male …

The adult heart is a post-mitotic terminally differentiated organ; therefore, beyond
development, cardiomyocyte cell death is maladaptive. Heart disease is the leading cause …

Loss of cardiac myocytes in heart failure is thought to occur largely through an apoptotic
process. Here we show that heart failure can also be precipitated through myocyte necrosis …

Loss of myocardial cells via apoptosis has been observed in many cardiovascular diseases
and has been shown to contribute to the initiation and progression of heart failure. The Bcl-2 …

Although several studies have shown that the administration of 17β-estradiol (estrogen) is
cardioprotective to ischemia-reperfusion (I/R), the molecular mechanisms are largely …

Background: Obesity is often associated with the development of heart failure, but the
precise mechanisms remain uncertain. The purpose of this study was to evaluate the key …