OBJECTIVE: To investigate astaxanthin (AST) protecting myocardial cells from
hypoxia/reoxygenation (H/R) injury by regulating miR-138/HIF-1α axis. MATERIALS AND …

Abstract The 3S, 3'S‑ASTaxanthin (3S, 3'S‑AST) isomer has strong antioxidant activity;
however, its protective roles and potential mechanisms against oxidative stress damage in …

Introduction: The protective effects of astaxanthin against myocardial ischemia-reperfusion
injuries are well documented, although the mechanisms are not defined. Methods: The …

Asiatic acid (AA) could attenuate ischemia/reperfusion induced myocardial apoptosis
through upregulating the Akt/GSK‐3β/HIF‐1α pathway. HIF‐3α is a negative regulator of HIF …

Purpose Pirarubicin (THP) is an antitumour drug widely used in clinical practice, but its
cardiotoxicity limits its application. THP cardiotoxicity must be treated as soon as possible …

Objective To investigate the protective effect of hydroxysafflor yellow A (HSYA) on oxidative
damage in cardiomyocytes, and to further observe the relationship between this effect and …

Coronary microembolization (CME) caused by physical obstruction in coronary
microcirculation induces myocardial apoptosis and cardiac dysfunction, and it was reported …

The aim of the present study was to investigate the role of microRNAs (miRNAs/miRs) in the
anti‑fibrotic effect of astaxanthin (AST), using the human hepatic stellate cell (HSC) line LX‑2 …

Objective To study the protective effect of rosmarinic acid (Ros A) on the primary
cardiomyocyte hypoxia/reoxygenation (H/R) injury. Method Primary cardiomyocytes of rats …

The aim is to investigate the mechanism of miR‐499a‐5p on the damage of cardiomyocyte
induced by hypoxia/reoxygenation. The activity of lactate dehydrogenase (LDH), apoptosis …