5-Nitro-thiophene-thiosemicarbazone derivatives present antitumor activity mediated by apoptosis and DNA intercalation
KM Roque Marques, MR do Desterro… - Current Topics in …, 2019 - ingentaconnect.com
Background: Considering the need for the development of new antitumor drugs, associated
with the great antitumor potential of thiophene and thiosemicarbazonic derivatives, in this …
with the great antitumor potential of thiophene and thiosemicarbazonic derivatives, in this …
Design, synthesis, cytotoxic screening and molecular docking studies of novel hybrid thiosemicarbazone derivatives as anticancer agents
FZ Mohammed, YW Rizzk, IM El Deen… - Chemistry & …, 2021 - Wiley Online Library
Thiosemicarbazones have been the focus of scientists owing to their broad clinical
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …
Synthesis of thiophene-thiosemicarbazone derivatives and evaluation of their in vitro and in vivo antitumor activities
JF de Oliveira, AL da Silva… - European journal of …, 2015 - Elsevier
A series of thiophene-2-thiosemicarbazones derivatives (5–14) was synthesized,
characterized and evaluated for their antitumor activity. They were tested in vitro against …
characterized and evaluated for their antitumor activity. They were tested in vitro against …
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo [b] thiophene derivatives
A Martorana, C Gentile, U Perricone… - European Journal of …, 2015 - Elsevier
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo [b] thiophenes and the parent amino
derivatives were synthesized and screened as antitumor agents. All tested compounds …
derivatives were synthesized and screened as antitumor agents. All tested compounds …
Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase …
JF de Oliveira, TS Lima, DB Vendramini-Costa… - European journal of …, 2017 - Elsevier
In this study, we report the synthesis and structural characterization of a series of
thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative …
thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative …
Synthesis, cytotoxic evaluation, docking and in silico pharmacokinetic prediction of 4-arylideneamino/cycloalkylidineamino 1, 2-naphthoquinone thiosemicarbazones
S Shukla, RS Srivastava, SK Shrivastava… - Journal of Enzyme …, 2013 - Taylor & Francis
In an attempt to develop potent anticancer agents, a series of 4-arylideneamino/
cycloalkylidineamino-1, 2-naphthoquinone thiosemicarbazones were synthesized and …
cycloalkylidineamino-1, 2-naphthoquinone thiosemicarbazones were synthesized and …
Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative …
The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore,
crystal and molecular structure of 4-diethylamino-salicylaldehyde 4 …
crystal and molecular structure of 4-diethylamino-salicylaldehyde 4 …
Design, synthesis, biological and computational assessment of new thiazolidin‐4‐one derivatives as potential anticancer agents through the apoptosis pathway
A variety of novel thiazolidin‐4‐one himachalene derivatives were designed and
synthesized through hetero‐cyclization of thiosemicarbazone analogs that have previously …
synthesized through hetero‐cyclization of thiosemicarbazone analogs that have previously …
Structural and functional insight into thiazolidinone derivatives as novel candidates for anticancer drug design: in vitro biological and in-silico strategies
The compounds 2a–2h containing a thiazolidinone pharmacophore were synthesized via
hetrerocylization of thiosemicarbazones with dimethyl acetylenedicarboxylate. The hybrid …
hetrerocylization of thiosemicarbazones with dimethyl acetylenedicarboxylate. The hybrid …
Synthesis, Characterization, and Molecular Docking of Novel bis‐thiazolyl Thienothiophene Derivatives as Promising Cytotoxic Antitumor Drug
SM Gomha, MA El‐Hashash… - Journal of …, 2017 - Wiley Online Library
A novel, facile reaction for the synthesis of series of bis‐thiazole derivatives has been
developed from the reaction of the appropriate thiosemicarbazone derivatives and bis‐2 …
developed from the reaction of the appropriate thiosemicarbazone derivatives and bis‐2 …
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