5-Nitro-thiophene-thiosemicarbazone derivatives present antitumor activity mediated by apoptosis and DNA intercalation

KM Roque Marques, MR do Desterro… - Current Topics in …, 2019 - ingentaconnect.com
Background: Considering the need for the development of new antitumor drugs, associated
with the great antitumor potential of thiophene and thiosemicarbazonic derivatives, in this …

Design, synthesis, cytotoxic screening and molecular docking studies of novel hybrid thiosemicarbazone derivatives as anticancer agents

FZ Mohammed, YW Rizzk, IM El Deen… - Chemistry & …, 2021 - Wiley Online Library
Thiosemicarbazones have been the focus of scientists owing to their broad clinical
anticancer range. Herein, A Series of new thiosemicarbazone derivatives 5–9 were …

Synthesis of thiophene-thiosemicarbazone derivatives and evaluation of their in vitro and in vivo antitumor activities

JF de Oliveira, AL da Silva… - European journal of …, 2015 - Elsevier
A series of thiophene-2-thiosemicarbazones derivatives (5–14) was synthesized,
characterized and evaluated for their antitumor activity. They were tested in vitro against …

Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo [b] thiophene derivatives

A Martorana, C Gentile, U Perricone… - European Journal of …, 2015 - Elsevier
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo [b] thiophenes and the parent amino
derivatives were synthesized and screened as antitumor agents. All tested compounds …

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase …

JF de Oliveira, TS Lima, DB Vendramini-Costa… - European journal of …, 2017 - Elsevier
In this study, we report the synthesis and structural characterization of a series of
thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative …

Synthesis, cytotoxic evaluation, docking and in silico pharmacokinetic prediction of 4-arylideneamino/cycloalkylidineamino 1, 2-naphthoquinone thiosemicarbazones

S Shukla, RS Srivastava, SK Shrivastava… - Journal of Enzyme …, 2013 - Taylor & Francis
In an attempt to develop potent anticancer agents, a series of 4-arylideneamino/
cycloalkylidineamino-1, 2-naphthoquinone thiosemicarbazones were synthesized and …

Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative …

I Đilović, M Rubčić, V Vrdoljak, SK Pavelić… - Bioorganic & medicinal …, 2008 - Elsevier
The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore,
crystal and molecular structure of 4-diethylamino-salicylaldehyde 4 …

Design, synthesis, biological and computational assessment of new thiazolidin‐4‐one derivatives as potential anticancer agents through the apoptosis pathway

A Bimoussa, A Oubella, I Bjij, M Fawzi… - …, 2022 - Wiley Online Library
A variety of novel thiazolidin‐4‐one himachalene derivatives were designed and
synthesized through hetero‐cyclization of thiosemicarbazone analogs that have previously …

Structural and functional insight into thiazolidinone derivatives as novel candidates for anticancer drug design: in vitro biological and in-silico strategies

PA Channar, M Aziz, SA Ejaz… - Journal of …, 2023 - Taylor & Francis
The compounds 2a–2h containing a thiazolidinone pharmacophore were synthesized via
hetrerocylization of thiosemicarbazones with dimethyl acetylenedicarboxylate. The hybrid …

Synthesis, Characterization, and Molecular Docking of Novel bis‐thiazolyl Thienothiophene Derivatives as Promising Cytotoxic Antitumor Drug

SM Gomha, MA El‐Hashash… - Journal of …, 2017 - Wiley Online Library
A novel, facile reaction for the synthesis of series of bis‐thiazole derivatives has been
developed from the reaction of the appropriate thiosemicarbazone derivatives and bis‐2 …