Apoptosis and nuclear levels of p53 protein and proliferating cell nuclear antigen in human hepatoma cells cultured with tumor promoters
Y Kaneko, A Tsukamoto - Cancer letters, 1995 - Elsevier
Anticancer drugs etoposide and mitomycin C increased nuclear p53 protein and decreased
proliferating cell nuclear antigen (PCNA) of PLC/PRF/5 human hepatoma cells. These …
proliferating cell nuclear antigen (PCNA) of PLC/PRF/5 human hepatoma cells. These …
Apoptosis and p53 protein expression in human hepatoma cells induced by etoposide, mitomycin C and thapsigargin
Y Kaneko, A Tsukamoto - International Hepatology Communications, 1994 - Elsevier
We found that the anti-cancer drugs of mitomycin C and etoposide will induce chromatin
decondensation in human PLC/PRF/5 hepatoma cells, while the tumor promoter …
decondensation in human PLC/PRF/5 hepatoma cells, while the tumor promoter …
p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion.
HE van Gijssel, CB Maassen, GJ Mulder… - …, 1997 - academic.oup.com
The tumour suppressor gene p53 is expressed in response to DNA-damage; its protein
product blocks cells in the G1-phase of the cell cycle. This gives cells additional time to …
product blocks cells in the G1-phase of the cell cycle. This gives cells additional time to …
Relation between p53 expression of human colon cancer cell lines and induction of apoptosis by anticancer drugs
N Matsuhashi, A Matsuo, Y Kawaguchi… - Gan to Kagaku ryoho …, 2003 - europepmc.org
The relation between p53 expression of human colon cancer cell lines and induction of
apoptosis by anticancer drugs was examined experimentally. HCT116 had wild-type p53 …
apoptosis by anticancer drugs was examined experimentally. HCT116 had wild-type p53 …
Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.
M Fritsche, C Haessler, G Brandner - Oncogene, 1993 - europepmc.org
Cancer therapy drugs, such as diamminedichloroplatinum (cisplatin), mitomycin C,
etoposide and a number of other compounds, as well as energy-rich radiation, are known to …
etoposide and a number of other compounds, as well as energy-rich radiation, are known to …
Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells.
MC Jiang, HF Yang-Yen, JK Lin, JJ Yen - Oncogene, 1996 - europepmc.org
Apoptosis of HepG2 cells triggered by various agents is characterized in an attempt to
delineate the common apoptosis signaling pathway in human hepatoma cells. Several …
delineate the common apoptosis signaling pathway in human hepatoma cells. Several …
Doxorubicin and octreotide induce a 40 kDa breakdown product of p53 in human hepatoma and tumoral colon cell lines
Z Sadji-Ouatas, M Lasfer, S Julien… - Biochemical …, 2002 - portlandpress.com
The chemotherapeutic drug doxorubicin and the anti-proliferative long-acting somatostatin
analogue octreotide, both used in cancer treatment, have been shown to increase the …
analogue octreotide, both used in cancer treatment, have been shown to increase the …
Wild-type function of the p53 tumor suppressor protein is not required for apoptosis of mouse hepatoma cells
C Unger, A Buchmann, CL Bünemann… - Cell Death & …, 1998 - nature.com
The role of the tumor suppressor protein p53 in apoptosis of mouse hepatoma cells was
studied. Different lines were used which were either p53 wild-type or carried various types of …
studied. Different lines were used which were either p53 wild-type or carried various types of …
The p53 tumor suppressor gene in anticancer agent-induced apoptosis and chemosensitivity of human gastrointestinal cancer cell lines
M Yamamoto, Y Maehara, S Oda, Y Ichiyoshi… - Cancer chemotherapy …, 1999 - Springer
Purpose: While the target of many anticancer agents has been identified, the processes
leading to killing of the cancer cells and the molecular basis of resistance to the drugs are …
leading to killing of the cancer cells and the molecular basis of resistance to the drugs are …
Tumor promoters as inhibitors of apoptosis in rat hepatocytes
D Schrenk, HJ Schmitz, S Bohnenberger, B Wagner… - Toxicology letters, 2004 - Elsevier
Multistage carcinogenesis in rat liver is widely used as an experimental model for the study
of the critical events in tumor promotion. After an initial treatment with a genotoxic liver …
of the critical events in tumor promotion. After an initial treatment with a genotoxic liver …