Shear Stress–Induced Endothelial Cell Migration Involves Integrin Signaling Via the Fibronectin Receptor Subunits α5 and β1
C Urbich, E Dernbach, A Reissner, M Vasa… - … , and vascular biology, 2002 - Am Heart Assoc
Endothelial cell (EC) migration is required for angiogenesis, neovascularization, and
reendothelialization. Integrins, known as αβ-heterodimeric cell-surface receptors, regulate …
reendothelialization. Integrins, known as αβ-heterodimeric cell-surface receptors, regulate …
Mechanotransduction in endothelial cell migration
The migration of endothelial cells (ECs) plays an important role in vascular remodeling and
regeneration. EC migration can be regulated by different mechanisms such as chemotaxis …
regeneration. EC migration can be regulated by different mechanisms such as chemotaxis …
Laminar shear stress upregulates integrin expression: role in endothelial cell adhesion and apoptosis
C Urbich, DH Walter, AM Zeiher, S Dimmeler - Circulation research, 2000 - Am Heart Assoc
Laminar shear stress exerts important effects on endothelial cell (EC) function and inhibits
apoptosis of ECs induced by various stimuli. The mechanism by which hemodynamic forces …
apoptosis of ECs induced by various stimuli. The mechanism by which hemodynamic forces …
Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system
HQ Wang, LX Huang, MJ Qu, ZQ Yan, B Liu… - Endothelium, 2006 - Taylor & Francis
Vascular endothelial cells (ECs) are constantly exposed to blood flow–induced shear stress;
these forces strongly influence the behaviors of neighboring vascular smooth muscle cells …
these forces strongly influence the behaviors of neighboring vascular smooth muscle cells …
Altered shear stress on endothelial cells leads to remodeling of extracellular matrix and induction of angiogenesis
Endothelial cells (ECs) are subjected to physical forces such as shear stress (SS) induced
by blood flow that leads to significant changes in morphology, physiology and gene …
by blood flow that leads to significant changes in morphology, physiology and gene …
Eosinophil adhesion under flow conditions activates mechanosensitive signaling pathways in human endothelial cells
SL Cuvelier, S Paul, N Shariat, P Colarusso… - The Journal of …, 2005 - rupress.org
Leukocyte transmigration can be affected by shear stress; however, the mechanisms by
which shear stress modulates transmigration are unknown. We found that adhesion of …
which shear stress modulates transmigration are unknown. We found that adhesion of …
Shear stress augments the endothelial cell differentiation marker expression in late EPCs by upregulating integrins
X Cui, X Zhang, X Guan, H Li, X Li, H Lu… - … and Biophysical Research …, 2012 - Elsevier
Vascular endothelial cell injury has been implicated in the onset of atherosclerosis. A
number of previous studies have demonstrated that endothelial progenitor cells (EPCs), in …
number of previous studies have demonstrated that endothelial progenitor cells (EPCs), in …
Localized α4 Integrin Phosphorylation Directs Shear Stress–Induced Endothelial Cell Alignment
LE Goldfinger, E Tzima, R Stockton… - Circulation …, 2008 - Am Heart Assoc
Vascular endothelial cells respond to laminar shear stress by aligning in the direction of
flow, a process which may contribute to atheroprotection. Here we report that localized α4 …
flow, a process which may contribute to atheroprotection. Here we report that localized α4 …
Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress
M Takahashi, T Ishida, O Traub, MA Corson… - Journal of vascular …, 1997 - karger.com
Fluid shear stress is one of the most important mechanical forces acting upon vascular
endothelium, because of its location at the interface between the bloodstream and vascular …
endothelium, because of its location at the interface between the bloodstream and vascular …
Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement
M Cheng, X Guan, H Li, X Cui, X Zhang, X Li, X Jing… - PLoS …, 2013 - journals.plos.org
Background Previous studies have demonstrated that endothelial progenitor cells (EPCs), in
particular late EPCs, play important roles in endothelial maintenance and repair. Recent …
particular late EPCs, play important roles in endothelial maintenance and repair. Recent …
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