Shear Stress–Induced Endothelial Cell Migration Involves Integrin Signaling Via the Fibronectin Receptor Subunits α5 and β1

C Urbich, E Dernbach, A Reissner, M Vasa… - … , and vascular biology, 2002 - Am Heart Assoc
Endothelial cell (EC) migration is required for angiogenesis, neovascularization, and
reendothelialization. Integrins, known as αβ-heterodimeric cell-surface receptors, regulate …

Mechanotransduction in endothelial cell migration

S Li, NF Huang, S Hsu - Journal of cellular biochemistry, 2005 - Wiley Online Library
The migration of endothelial cells (ECs) plays an important role in vascular remodeling and
regeneration. EC migration can be regulated by different mechanisms such as chemotaxis …

Laminar shear stress upregulates integrin expression: role in endothelial cell adhesion and apoptosis

C Urbich, DH Walter, AM Zeiher, S Dimmeler - Circulation research, 2000 - Am Heart Assoc
Laminar shear stress exerts important effects on endothelial cell (EC) function and inhibits
apoptosis of ECs induced by various stimuli. The mechanism by which hemodynamic forces …

Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system

HQ Wang, LX Huang, MJ Qu, ZQ Yan, B Liu… - Endothelium, 2006 - Taylor & Francis
Vascular endothelial cells (ECs) are constantly exposed to blood flow–induced shear stress;
these forces strongly influence the behaviors of neighboring vascular smooth muscle cells …

Altered shear stress on endothelial cells leads to remodeling of extracellular matrix and induction of angiogenesis

TA Russo, AMM Banuth, HB Nader, JL Dreyfuss - PLoS One, 2020 - journals.plos.org
Endothelial cells (ECs) are subjected to physical forces such as shear stress (SS) induced
by blood flow that leads to significant changes in morphology, physiology and gene …

Eosinophil adhesion under flow conditions activates mechanosensitive signaling pathways in human endothelial cells

SL Cuvelier, S Paul, N Shariat, P Colarusso… - The Journal of …, 2005 - rupress.org
Leukocyte transmigration can be affected by shear stress; however, the mechanisms by
which shear stress modulates transmigration are unknown. We found that adhesion of …

Shear stress augments the endothelial cell differentiation marker expression in late EPCs by upregulating integrins

X Cui, X Zhang, X Guan, H Li, X Li, H Lu… - … and Biophysical Research …, 2012 - Elsevier
Vascular endothelial cell injury has been implicated in the onset of atherosclerosis. A
number of previous studies have demonstrated that endothelial progenitor cells (EPCs), in …

Localized α4 Integrin Phosphorylation Directs Shear Stress–Induced Endothelial Cell Alignment

LE Goldfinger, E Tzima, R Stockton… - Circulation …, 2008 - Am Heart Assoc
Vascular endothelial cells respond to laminar shear stress by aligning in the direction of
flow, a process which may contribute to atheroprotection. Here we report that localized α4 …

Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress

M Takahashi, T Ishida, O Traub, MA Corson… - Journal of vascular …, 1997 - karger.com
Fluid shear stress is one of the most important mechanical forces acting upon vascular
endothelium, because of its location at the interface between the bloodstream and vascular …

Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement

M Cheng, X Guan, H Li, X Cui, X Zhang, X Li, X Jing… - PLoS …, 2013 - journals.plos.org
Background Previous studies have demonstrated that endothelial progenitor cells (EPCs), in
particular late EPCs, play important roles in endothelial maintenance and repair. Recent …