Adult neurogenesis occurs in the subgranular zone of the hippocampal dentate gyrus and
the subventricular zone of the lateral ventricles. This process is highly regulated by intrinsic …

Aging is accompanied by an alteration of spatial memory, which has been related to an
alteration in hippocampal plasticity. Within the dentate gyrus, new neurons are generated …

Age-related changes in neurogenesis and its modulation by caloric restriction (CR) were
studied in C57BL/6 mice. To this end, bromodeoxyuridine (BrdU) labeling was used to …

New neurons are continually generated in the adult hippocampus, but the important
question, whether adult neurogenesis is transient or leads to the lasting presence of new …

Hippocampal neuron loss is widely viewed as a hallmark of normal aging. Moreover,
neuronal degeneration is thought to contribute directly to age-related deficits in learning and …

The hippocampus is a structure equipped with a high degree of flexibility and adaptation. In
contrast to most structures of the adult central nervous system, the hippocampus can rely on …

The dentate gyrus of the hippocampus generates neurons throughout life, but adult
neurogenesis exhibits a marked age‐dependent decline. Although the decrease in the rate …

Mechanisms of cognitive decline with aging remain primarily unknown. We determined
whether localized cell loss occurred in brain regions associated with age-related cognitive …

Recent studies have shown that neurogenesis in the dentate gyrus of the rodent
hippocampus continues throughout life. Several physiological and pathological conditions …

The production of hippocampal granule neurons continues throughout adulthood but
dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged …