▪ Abstract Multiple carboxylesterases (EC 3.1. 1.1) play an important role in the hydrolytic
biotransformation of a vast number of structurally diverse drugs. These enzymes are major …

Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

A cDNA clone was isolated from a rat liver lambda gt11 expression library by screening with
polyclonal antibodies raised against a rat liver microsomal carboxylesterase. This clone of …

Introduction: Carboxylesterases play major roles in the hydrolysis of numerous
therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety …

Carboxylesterases (CEs) are traditionally regarded as xenobiotic metabolizing enzymes that
hydrolyze esterified xenobiotics to alcohol and carboxylic acid products. However, there is a …

This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

Multiple forms of carboxylesterase have been identified in rat liver, and five
carboxylesterases (designated hydrolases A, B, C, S, and egasyn) have been cloned …

Hydrolase activity from human liver and small intestine microsomes was compared with that
of recombinant human carboxylesterases, hCE-1 and hCE-2. Although both hCE-1 and hCE …

Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase
superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and …

The mammalian carboxylesterases (CESs) comprise a multigene family which gene
products play important roles in biotransformation of ester-or amide-type prodrugs. Since …