[HTML][HTML] Smarter drugs emerging in pancreatic cancer therapy

A Kleger, L Perkhofer, T Seufferlein - Annals of Oncology, 2014 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer death in
the Western world. Owing to a lack of specific symptoms and no accessible precursor …

Pharmacotherapeutic strategies for treating pancreatic cancer: advances and challenges

M Diab, A Azmi, R Mohammad… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Despite many efforts to improve the outcome of pancreatic ductal
adenocarcinoma (PDAC), its prognosis remains poor, which is mostly related to late …

Targeted therapies in pancreatic cancer: promises and failures

M Barati Bagherabad, F Afzaljavan… - Journal of Cellular …, 2019 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is an incidence rate nearly equal to its mortality
rate. The poor prognosis of the disease can be explained by the absence of effective …

[HTML][HTML] Recent advances in targeted therapy for pancreatic adenocarcinoma

YT Fang, WW Yang, YR Niu, YK Sun - World journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic adenocarcinoma (PDAC) is a fatal disease with a 5-year survival rate of 8% and
a median survival of 6 mo. In PDAC, several mutations in the genes are involved, with …

Challenges and future directions in therapeutics for pancreatic ductal adenocarcinoma

AHI Al Haddad, TE Adrian - Expert opinion on investigational drugs, 2014 - Taylor & Francis
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of
cancer death in the USA. The 5-year survival of< 5% has not changed in decades. In …

Target therapies in pancreatic carcinoma

N Silvestris, A Gnoni… - Current medicinal …, 2014 - ingentaconnect.com
Pancreatic ductal adenocarcinoma (PDAC) occurs in the majority of cases with early
locoregional spread and distant metastases at diagnosis, leading to dismal prognosis and …

Pancreatic ductal adenocarcinoma: State-of-the-art 2017 and new therapeutic strategies

M Chiaravalli, M Reni, EM O'Reilly - Cancer treatment reviews, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy with an overall 5-year
survival of 8% for all stages combined. The majority of patients present with stage IV disease …

Emerging drugs in the treatment of pancreatic cancer

D Mahalingam, KR Kelly, RT Swords… - Expert opinion on …, 2009 - Taylor & Francis
Background: Pancreatic cancer is the fourth leading cause of cancer-related death in the
US. However, there is a growing belief that novel biological agents could improve survival of …

Challenges in developing targeted therapy for pancreatic adenocarcinoma

D Mahalingam, F Giles - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Background: Pancreatic adenocarcinoma is a leading cause of cancer deaths in the US.
Gemcitabine-based chemotherapy remains the cornerstone treatment for advanced …

Current standard and future perspectives in first-and second-line treatment of metastatic pancreatic adenocarcinoma

V Ellenrieder, A König, T Seufferlein - Digestion, 2016 - karger.com
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy
with a median 5-year survival of< 8%. At the time of diagnosis, a vast majority of pancreatic …