Background T helper (TH) 17 cells are believed to play a pivotal role in development of
inflammatory bowel disease, and their contribution to intestinal inflammation has been …

Background IL-23/TH17 inflammatory responses are regarded as central to the
pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown …

Evaluation of: Wedebye Schmidt EG, Larsen HL, Kristensen N et al. Th17 cell induction and
effects of IL-17A and IL-17F blockade in experimental colitis. Inflamm. Bowel Dis. 19 (8) …

Background and Aims T helper 17 [Th17] cells are crucially involved in the
immunopathogenesis of inflammatory bowel diseases in humans. Nevertheless …

Abstract Both Th1 and Th17 cells have been implicated in the pathogenesis of inflammatory
bowel disease and experimental colitis. However, the complex relationship between Th1 …

Background & Aims: Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17
(Th17) that can mediate chronic inflammation. This study was performed to define the role of …

The recent discovery and characterization of T helper 17 cells (Th17) and their signature
cytokines (IL-17) represents a hallmark in T-cell immunobiology by providing a new …

Background Th17 cells play a role in inflammation. Interleukin (IL)-10 is a potent anti-
inflammatory cytokine. However, it is poorly understood whether and how endogenous IL-10 …

T helper (Th) 17 cells and other interleukin (IL)-17-producing cells are supposed to play
critical roles in several human immune-mediated diseases, including Crohn's disease (CD) …

Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative
colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response …