The development of inhibitors for protein–protein interactions frequently involves the mimicry
of secondary structure motifs. While helical protein–protein interactions have been heavily …

Synthetic inhibitors of protein− protein interactions are being discovered despite the inherent
challenge in targeting large contact surfaces with small molecules. An analysis of available …

Protein–protein interactions have essential roles at almost every level of organization and
communication in living cells. During complex formation, proteins can interact via covalent …

Assessment of helical interfaces in protein – protein interactions - Molecular BioSystems (RSC
Publishing) DOI:10.1039/B903202A Royal Society of Chemistry View PDF VersionPrevious …

Protein–protein interactions encompass large surface areas, but often a handful of key
residues dominate the binding energy landscape. Rationally designed small molecule …

The modulation of protein–protein interactions (PPIs) by means of creating or stabilizing
secondary structure conformations is a rapidly growing area of research. Recent success in …

Due to the pivotal roles that protein-protein interactions play in a plethora of biological
processes, the design of therapeutic agents targeting these interactions has become an …

Protein secondary structures serve as geometrically constrained scaffolds for the display of
key interacting residues at protein interfaces. Given the critical role of secondary structures …

The transient assembly of multiprotein complexes mediates many aspects of cell regulation
and signalling in living organisms. Modulation of the formation of these complexes through …

Although targeting protein–protein interfaces of regulatory multiprotein complexes has
become a significant focus in drug discovery, it continues to pose major challenges. Most …