From antimicrobial to anticancer peptides: the transformation of peptides

Y Qin, ZD Qin, J Chen, CG Cai, L Li… - Recent patents on …, 2019 - ingentaconnect.com
Background: Antimicrobial peptides play an important role in the innate immune system.
Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat …

Antimicrobial and anticancer peptides

NM O'Brien-Simpson, R Hoffmann, CSB Chia… - Frontiers in …, 2018 - frontiersin.org
The World Health Organization (WHO) in their 2014 report describe cancer as “one of the
leading causes of morbidity and mortality worldwide” and is the second leading cause of …

Designed antimicrobial and antitumor peptides with high selectivity

J Hu, C Chen, S Zhang, X Zhao, H Xu, X Zhao… - …, 2011 - ACS Publications
We report a new class of cationic amphiphilic peptides with short sequences, G (IIKK) n I-
NH2 (n= 1–4), that can kill Gram-positive and Gram-negative bacteria as effectively as …

Peptides with dual antimicrobial–anticancer activity: Strategies to overcome peptide limitations and rational design of anticancer peptides

Y Liscano, J Oñate-Garzón, JP Delgado - Molecules, 2020 - mdpi.com
Peptides are naturally produced by all organisms and exhibit a wide range of physiological,
immunomodulatory, and wound healing functions. Furthermore, they can provide with …

Bacterial proteins and peptides in cancer therapy: today and tomorrow

AM Chakrabarty, N Bernardes, AM Fialho - Bioengineered, 2014 - Taylor & Francis
Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts
have been made focused on understanding how cancer grows and responds to drugs. The …

Anti-cancer peptides: Their current trends in the development of peptide-based therapy and anti-tumor drugs

A Lath, AR Santal, N Kaur, P Kumari… - Biotechnology and …, 2023 - Taylor & Francis
Human cancer remains a cause of high mortality throughout the world. The conventional
methods and therapies currently employed for treatment are followed by moderate-to-severe …

From antimicrobial to anticancer peptides. A review

D Gaspar, AS Veiga, MARB Castanho - Frontiers in microbiology, 2013 - frontiersin.org
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many
organisms. Although AMPs have been essentially studied and developed as potential …

Peptides: a new class of anticancer drugs

R Smolarczyk, T Cichoń, S Szala - Postepy Higieny i Medycyny …, 2009 - europepmc.org
Peptides are a novel class of anticancer agents embracing two distinct categories: natural
antibacterial peptides, which are preferentially bound by cancer cells, and chemically …

Anticancer activities of natural and synthetic peptides

AL Hilchie, DW Hoskin, MR Power Coombs - … Peptides: Basics for Clinical …, 2019 - Springer
Anticancer peptides (ACPs) are cationic amphipathic peptides that bind to and kill cancer
cells either by a direct-or indirect-acting mechanism. ACPs provide a novel treatment …

A new era of antibiotics: the clinical potential of antimicrobial peptides

K Browne, S Chakraborty, R Chen… - International journal of …, 2020 - mdpi.com
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health.
The traditional antibiotic pipeline has been exhausted, prompting research into alternate …