Merging old and new perspectives on nicotinic acetylcholine receptors

RL Papke - Biochemical pharmacology, 2014 - Elsevier
This review covers history underlying the discovery of the molecular mediators of nicotine's
effects in the brain and the diversity of the nicotinic acetylcholine receptor (nAChR) …

Nicotinic acetylcholine receptors: from structure to brain function

RC Hogg, M Raggenbass, D Bertrand - Reviews of physiology …, 2003 - Springer
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be
divided into two groups: muscle receptors, which are found at the skeletal neuromuscular …

The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice

N Wang, A Orr-Urtreger, AD Korczyn - Progress in neurobiology, 2002 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (α2–α10, β2–
β4), are expressed in autonomic ganglia, playing a central role in autonomic transmission …

Molecular diversity of neuronal nicotinic acetylcholine receptors

DS McGEHEE - Annals of the New York Academy of Sciences, 1999 - Wiley Online Library
The potent behavioral and cognitive effects of nicotine highlight the physiological
importance of nicotinic acetylcholine receptors (nAChRs). These receptors are part of the …

Selective α7 nicotinic acetylcholine receptor ligands

A Mazurov, T Hauser, CH Miller - Current medicinal chemistry, 2006 - ingentaconnect.com
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand gated ion channels of broad
distribution and structural heterogeneity. Their functional diversity demonstrated involvement …

The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex

M Alkondon, EX Albuquerque - Progress in brain research, 2004 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central nervous
system and have been implicated in multiple behavioral paradigms and pathological …

The role of neuronal nicotinic acetylcholine receptors in acute and chronic neurodegeneration

MJ O'neill, TK Murray, V Lakics… - Current Drug Targets …, 2002 - ingentaconnect.com
In the last five years there has been a rapid explosion of publications reporting that neuronal
nicotinic acetylcholine receptors (nAChRs) play a role in neurodegenerative disorders …

Human neuronal nicotinic receptors

C Gotti, D Fornasari, F Clementi - Progress in neurobiology, 1997 - Elsevier
Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative,
behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine …

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations

DK Williams, J Wang, RL Papke - Biochemical pharmacology, 2011 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug
development in cognitive and neuro-degenerative disorders, are allosteric proteins with …

Allosteric modulation of nicotinic acetylcholine receptors

A Chatzidaki, NS Millar - Biochemical pharmacology, 2015 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …