Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of cation channels widely
distributed in the brain, whose subunit composition and biophysical properties vary …

The plant alkaloid, nicotine (Fig. 1), is a commonly used psychoactive drug that is orally self-
administered via the chewing or combustion of tobacco products, the latter typically via …

Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh)
to coordinate neuronal circuit activity while simultaneously influencing the function of non …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the mammalian central
nervous system (CNS). Despite this, very little was known, until recently, about their …

A family of genes has been identified that encodes subunits of nicotinic acetylcholine
receptors (nAChRs) and is expressed in the nervous system. Functional neuronal nAChRs …

Neuronal nicotinic acetylcholine receptors (nAChRs) are widespread, diverse ion channels
involved in synaptic signaling, addiction, and disease. Despite their importance, the …

Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Accumulating data suggest that α7 nicotinic acetylcholine receptors (α7nAChRs) are an
important therapeutic target for the treatment of Alzheimer's disease (AD) and schizophrenia …

Neuronal nicotinic acetylcholine receptors (nAChRs) in the CNS appear to exert a
predominantly modulatory influence on brain mechanisms, despite being fast-acting ligand …

HEK293 cells were stably transfected with the cDNAs encoding full-length human neuronal
nicotinic acetylcholine receptor (nAChR) subunit combinations α3β2 or α4β2.[3H]-(±) …