The neuronal nicotinic acetylcholine receptors (nAChRs) in the brain are important for
functional processes, including cognitive and memory functions. The nAChRs acting as …

In the last decade, nicotinic acetylcholine receptors (nAChRs) have emerged as important
targets for drug discovery. The therapeutic potential of nicotinic agonists depends …

Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …

Nicotinic ACh receptors (nAChRs) can undergo desensitization, a reversible reduction in
response during sustained agonist application. Although the mechanism of desensitization …

Nicotinic acetylcholine receptors (nAChRs) are members of an extensive super-family of
neurotransmitter-gated ion channels. In humans, nAChRs are expressed within the nervous …

The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it
maintains various neuronal functions including (but not limited to) learning and memory. In …

Ijigand-gated ion channels providefor the rapid dialogue between cells of the central
nervous system, converting a chemical neurotransmitter signalreleased from one cell into an …

Nicotinic acetylcholine receptors (nAChRs) display a broad variety of subtypes, which in turn
present a complex subcellular and regional expression pattern in the brain, as well as a …

The growing interest in nicotinic receptors, because of their wide expression in neuronal and
non‐neuronal tissues and their involvement in several important CNS pathologies, has …

Nicotinic acetylcholine receptors (nAChRs) are ligand‐gated pentameric cation channels of
α and β subunits. The α5 subunit, when added to heteromeric complexes, alters …