Pulmonary surfactant protein D (SP-D), a member of the collectin family, is an innate
immune molecule critical for defense that can also modulate adaptive immune responses …

BACKGROUND: Surfactant protein (SP) D has been proposed to be protective in allergic
airway responses. OBJECTIVE: We aimed to determine the effect of SP-D deficiency on …

The lung is continuously exposed to inhaled pollutants, microbes and allergens. Therefore,
the pulmonary immune system has to defend against harmful pathogens, while an …

Surfactant protein D (SP-D) is a member of the collectin family of the innate host defense
proteins. In the lung, SP-D is expressed primarily by type II cells. Gene-targeted SP-D …

Surfactant protein (SP)-D, a 43-kD multifunctional collagen-like lectin, is synthesized and
secreted by the airway epithelium. SP-D knockout (SP-D [−/−]) mice exhibit an increase in …

Pulmonary surfactant, a complex of lipids and proteins, functions to keep alveoli from
collapsing at expiration. Surfactant proteins A (SP-A) and D (SP-D) belong to the collectin …

Surfactant protein D (SP-D) is a member of the collectin subfamily of C-type lectins, pattern
recognition proteins participating in the innate immune response. Gene-targeted mice …

DENDRITIC CELLS (DC) are the sentinels of the immune system, constantly surveying the
environment for the presence of foreign invaders (13, 14). In addition, these cells function as …

Abstract Surfactant protein D (SP‐D) is part of the innate immune system involved in lung
homeostasis. SP‐D knockout mice show accumulations of foamy alveolar macrophages …

Increased levels of surfactant protein D (SP-D) and lipid-laden foamy macrophages (FMs)
are frequently found under oxidative stress conditions and/or in patients with chronic …