Surfactant protein D has multiple functions in innate immunity in the lung. The generation of
SP-D knock-out mice has revealed a central role for this protein in the control of lung …

The pulmonary collectins, surfactant proteins A and D (SP-A and SP-D) have been
implicated in the regulation of the innate immune system within the lung. In particular, SP-D …

Abstract Surfactant protein D (SP-D) is a collectin protein synthesized by alveolar type II cells
in the lungs. SP-D participates in the innate immune defense of the lungs by helping to clear …

Pulmonary surfactant protein D (SP-D), a member of the collectin group of innate immune
proteins, plays important roles in lipopolysaccharide (LPS) recognition. We have previously …

Surfactant protein-D (SP-D) is a regulator of pulmonary innate immunity whose oligomeric
state can be altered through S-nitrosylation to regulate its signaling function in …

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are
major causes of acute respiratory failure with high rates of morbidity and mortality. Although …

Surfactant protein D (SP-D), a 43-kDa member of the collectin family of innate defense
molecules, is expressed primarily in the respiratory epithelium. Targeted deletion of the SP …

Lung surfactant protein-D (SP-D), a collectin mainly produced by alveolar type II cells,
initiates the effector mechanisms of innate immunity on binding to microbial carbohydrates …

BACKGROUND: Surfactant protein D (SP-D) is a member of the family of proteins termed
collagen-like lectins or “collectins” that play a role in non-antibody-mediated innate immune …

BACKGROUND: Surfactant protein (SP)-D is an epithelial cell product of the distal air
spaces that aids uptake and clearance of inhaled pathogens and allergens. Allergic airway …