Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled by S-nitrosylation

CJ Guo, EN Atochina-Vasserman… - … of Physiology-Lung …, 2019 - journals.physiology.org
Surfactant protein-D (SP-D) is a regulator of pulmonary innate immunity whose oligomeric
state can be altered through S-nitrosylation to regulate its signaling function in …

Localization of lung surfactant protein D on mucosal surfaces in human tissues

J Madsen, A Kliem, I Tornøe, K Skjødt… - The Journal of …, 2000 - journals.aai.org
Lung surfactant protein-D (SP-D), a collectin mainly produced by alveolar type II cells,
initiates the effector mechanisms of innate immunity on binding to microbial carbohydrates …

Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism …

M Ohya, C Nishitani, H Sano, C Yamada… - Biochemistry, 2006 - ACS Publications
Pulmonary surfactant protein D (SP-D), a member of the collectin group of innate immune
proteins, plays important roles in lipopolysaccharide (LPS) recognition. We have previously …

IL-4 induces production of the lung collectin surfactant protein-D

Y Cao, JQ Tao, SR Bates, MF Beers… - Journal of allergy and …, 2004 - Elsevier
BACKGROUND: Surfactant protein (SP)-D is an epithelial cell product of the distal air
spaces that aids uptake and clearance of inhaled pathogens and allergens. Allergic airway …

Spontaneous emphysema in surfactant protein D gene-targeted mice

S Wert, T Jones, T Korfhagen, J Fisher, J Whitsett - Chest, 2000 - journal.chestnet.org
Surfactant protein D (SP-D), a 43-kDa member of the collectin family of innate defense
molecules, is expressed primarily in the respiratory epithelium. Targeted deletion of the SP …

Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo

TR Korfhagen, V Sheftelyevich, MS Burhans… - Journal of Biological …, 1998 - ASBMB
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin
domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene …

Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function

JF Alcorn, JR Wright - Journal of Biological Chemistry, 2004 - ASBMB
The alveolar epithelium is lined by surfactant, a lipoprotein complex that both reduces
surface tension and mediates several innate immune functions including bacterial …

[HTML][HTML] The dual role of surfactant protein-D in vascular inflammation and development of cardiovascular disease

KB Colmorten, AB Nexoe, GL Sorensen - Frontiers in Immunology, 2019 - frontiersin.org
Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is
the major cause of cardiovascular disease and is a chronic inflammatory disorder in the …

Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D

U Holmskov, J Mollenhauer… - Proceedings of the …, 1999 - National Acad Sciences
Surfactant protein D (SP-D) is an oligomeric C type lectin that promotes phagocytosis by
binding to microbial surface carbohydrates. A 340-kDa glycoprotein (gp-340) has been …

Surfactant protein D inhibits lipopolysaccharide-induced monocyte chemoattractant protein-1 expression in human renal tubular epithelial cells: implication for …

F Hu, W Liang, Z Ren, G Wang… - Clinical & Experimental …, 2012 - academic.oup.com
Summary Surfactant protein D (SP-D), a member of the C-type lectin (collectin) protein
family, plays a critical role in innate host defence against various microbial pathogens and in …