Platelets in host defense: experimental and clinical insights

L Nicolai, F Gaertner, S Massberg - Trends in immunology, 2019 - cell.com
Platelets are central players in thrombosis and hemostasis but are increasingly recognized
as key components of the immune system. They shape ensuing immune responses by …

The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Nouvelle cuisine: platelets served with inflammation

R Kapur, A Zufferey, E Boilard… - The Journal of …, 2015 - journals.aai.org
Platelets are small cellular fragments with the primary physiological role of maintaining
hemostasis. In addition to this well-described classical function, it is becoming increasingly …

Platelets as central mediators of systemic inflammatory responses

TL Smith, AS Weyrich - Thrombosis research, 2011 - Elsevier
Systemic inflammatory responses are associated with high morbidity and mortality and
represent a diverse and clinically challenging group of diseases. Platelets are increasingly …

Platelets as immune mediators: their role in host defense responses and sepsis

Z Li, F Yang, S Dunn, AK Gross, SS Smyth - Thrombosis research, 2011 - Elsevier
Platelets occupy a central role at the interface between thrombosis and inflammation. At
sites of vascular damage, adherent platelets physically and functionally interact with …

Role of platelets in detection and regulation of infection

I Portier, RA Campbell - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Platelets are classically known as essential mediators of hemostasis and thrombosis.
However, in recent years, platelets have gained recognition for their inflammatory functions …

Platelets: signaling cells in the immune continuum

AS Weyrich, GA Zimmerman - Trends in immunology, 2004 - cell.com
Platelets have intricate signaling mechanisms and participate in a breadth of cellular
interactions. This diversity is frequently unrecognized. In addition to being the chief cellular …

Emerging evidence for platelets as immune and inflammatory effector cells

MT Rondina, O Garraud - Frontiers in immunology, 2014 - frontiersin.org
While traditionally recognized for their roles in hemostatic pathways, emerging evidence
demonstrates that platelets have previously unrecognized, dynamic roles that span the …

Platelets and innate immunity

JW Semple, J Freedman - Cellular and Molecular Life Sciences, 2010 - Springer
Although platelets are best known as primary mediators of hemostasis, this function
intimately associates them with inflammatory processes, and it has been increasingly …

Blood platelets in infection: the multiple roles of the platelet signalling machinery

SMG Trivigno, GF Guidetti, SS Barbieri… - International Journal of …, 2023 - mdpi.com
Platelets are classically recognized for their important role in hemostasis and thrombosis but
they are also involved in many other physiological and pathophysiological processes …