The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

Objective—The importance of PI3K/Akt signaling in the vasculature has been demonstrated
in several models, as global loss of Akt1 results in impaired postnatal ischemia-and VEGF …

Akt, or protein kinase B, is a multifunctional serine-threonine protein kinase implicated in a
diverse range of cellular functions including cell metabolism, survival, migration, and gene …

The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1,
Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes …

Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible
remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as
migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the …

Regulation of endothelial cell apoptosis is a critical modulator of normal and pathological
angiogenesis. In this study, we examined the role of the protein kinase Akt/PKB in …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway is activated in the majority of human cancers. This pathway is known to play a key …