Endothelial cells are normally non-motile and quiescent; however, endothelial cells will
become permeable and invade and proliferate to form new blood vessels (angiogenesis) in …

The Akt/PKB isoforms have different roles in animals, with Akt2 primarily regulating
metabolic signaling and Akt1 regulating growth and survival. Here we show distinct roles for …

The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …

Akt serine/threonine kinases, or PKB, are key players in the regulation of a wide variety of
cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

In endothelial cells, transforming growth factor β (TGF-β) signals through two distinct
pathways to regulate endothelial cell proliferation and migration, the ALK-1/Smads 1/5/8 …

Antagonists of αvβ3 and αvβ5 disrupt angiogenesis in response to bFGF and VEGF,
respectively. Here, we show that these αv integrins differentially contribute to sustained Ras …

The Akt family of serine/threonine kinases includes Akt1, Akt2, and Akt3 isoforms. Prior
studies have reported that Akt1 and Akt2, but not Akt3, are expressed in platelets. Here, we …

Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …

Although multiple members of the phosphatidylinositol-3-kinase pathway (PI3K) are targeted
by germline or somatic mutations, functional mutations in the three akt isoforms have proven …