Background: Genetic processes underlying fetal lung development and maturation are
incompletely understood. Better knowledge of these processes would provide insights into …

Studies on lung morphogenesis have indicated a role of homeobox (Hox) genes in the
regulation of lung development. In the present study, we attempted to modulate the …

BACKGROUND: Hox transcription factors modulate signaling pathways controlling organ
morphogenesis and maintain cell fate and differentiation in adults. Retinoid signaling, key in …

Hox genes regulate organ formation and identity of the embryo, and expressed in specific
temporo-spatial patterns in the developing embryo. We compared the expression levels of …

Hox genes encode transcription factors governing complex developmental processes in
several organs. A subset of Hox genes are expressed in the developing lung. Except for …

BACKGROUND: We have previously shown that the Hox gene Hoxb‐5 is necessary for
normal mouse lung branching morphogenesis. Abnormal Hoxb‐5 regulation causes specific …

Hox proteins control structural morphogenesis, pattern formation and cell fate in the
developing embryo. To determine if Hoxb-5 participates in patterning of early airway …

The involvement of genes controlling embryonic processes in the etiology of diseases often
escapes attention because of the focus given to their inherent developmental role. Hoxa5 …

Hoxb5 and Hoxa5 transcription factor proteins uniquely impact lung morphogenesis at the
developmental time point when extremely preterm infants are born. The effect of O 2 …

Background Heme oxygenase (HO) degrades cellular heme to carbon monoxide, iron and
biliverdin. The HO-1 isoform is both inducible and cyto-protective during oxidative stress …