Rationale Severe, traumatic stress or repeated exposure to stress can result in long-term
deleterious effects, including hippocampal cell atrophy and death, which, in turn, result in …

Chronic stress in rats has been shown to impair learning and memory, and precipitate
several affective disorders like depression and anxiety. The mechanisms involved in these …

Medications that enhance dopaminergic neurotransmission can be useful in the
pharmacotherapy of posttraumatic stress disorder (PTSD), which manifests as fearful …

Background: It is well known that intense and prolonged stress can produce cognitive
impairments and hippocampal damage and increase noradrenergic activity in humans. This …

Brief exposure of mice to unavoidable predatory stimuli is associated with behavioral and
neurochemical changes consistent with increased anxiety [Belzung C, El Hage W, Moindrot …

Exposure to chronic stress is thought to play an important role in the etiology of depression.
In this disorder, dopaminergic dysfunction in the prefrontal cortex (PFC) is thought to be …

Background: Cortical dopamine and noradrenaline are involved in the stress response.
Citalopram, a selective serotonin reuptake inhibitor, has direct and indirect effects on the …

Stress-related behaviors are accompanied by modification of a large number of
neurotransmitters in the brain. Moreover, the binding to GABAA receptors does not account …

Central cholinergic (ACh) blockade produces profound cognitive impairments in human and
animal subjects. Our previous research demonstrated that ACh blockade exacerbates stress …

Stress exposure impairs the cognitive functioning of the prefrontal cortex (PFC). Previous
research has examined the dopamine (DA) D1 receptor mechanisms underlying this …