β-Adrenergic receptors (β-AR) increase epithelial sodium channel (ENaC) activity to
promote lung fluid clearance. However, the effect of selective β-AR agonist on highly …

It has been shown that short-term (hours) treatment with β-adrenergic agonists can stimulate
lung liquid clearance via augmented Na+ transport across alveolar epithelial cells. This …

Alveolar hypoxia may impair sodium-dependent alveolar fluid transport and induce
pulmonary edema in rat and human lung, an effect that can be prevented by the inhalation of …

Alveolar epithelial β-adrenergic receptor (βAR) activation accelerates active Na+ transport in
lung epithelial cells in vitro and speeds alveolar edema resolution in human lung tissue and …

β-Adrenergic agonists accelerate the clearance of alveolar fluid by increasing the
expression and activity of epithelial solute transport proteins such as amiloride-sensitive …

β2-adrenergic receptors are present throughout the lung, including the alveolar airspace,
where they play an important role for regulation of the active Na+ transport needed for …

We and others have shown that epithelial Na+ channels (ENaC) in alveolar type 2 (AT2)
cells are activated by β2 agonists, steroid hormones, elevated oxygen tension, and by …

In this review, we discuss evidence that supports the hypothesis that adrenergic stimulation
of transepithelial Na absorption across the alveolar epithelium occurs indirectly by activation …

In pulmonary epithelia, β-adrenergic agonists regulate the membrane abundance of the
epithelial sodium channel (ENaC) and, thereby, control the rate of transepithelial electrolyte …

Absorption of excess fluid from the airways and alveolar lumen requires active vectorial
transepithelial transport of sodium ions (Na+) by alveolar type II and possibly type I cells …