Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice

CL McMahon, EM Hurley, AM Perez, M Estrada… - JCI …, 2024 - Am Soc Clin Investig
Prenatal exposure to viral pathogens has been known to cause the development of
neuropsychiatric 26 disorders in adulthood. Furthermore, COVID-19 has been associated …

[HTML][HTML] Fetal brain vulnerability to SARS-CoV-2 infection

CL McMahon, J Castro, J Silvas, AM Perez… - Brain, Behavior, and …, 2023 - Elsevier
Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has
been controversial; however, recent evidence such as viral RNA detection in umbilical cord …

Impact of SARS-CoV-2 infection during pregnancy on postnatal brain development: The potential role of glial cells

LD Bobermin, LS Medeiros, FB Weber… - … Vol. 46, n. 12 (2022), p …, 2022 - lume.ufrgs.br
Glial cells are crucial for maintaining central nervous system (CNS) homeostasis. They
actively participate in immune responses, as well as form functional barriers, such as blood …

Consequences of viral infection and cytokine production during pregnancy on brain development in offspring

D Elgueta, P Murgas, E Riquelme, G Yang… - Frontiers in …, 2022 - frontiersin.org
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly
activating the maternal immune system, directly impacting fetal neural cells. Increasing …

COVID-19 in pregnancy: implications for fetal brain development

LL Shook, EL Sullivan, JO Lo, RH Perlis… - Trends in molecular …, 2022 - cell.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
during pregnancy on the developing fetal brain is poorly understood. Other antenatal …

SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders

H Dubey, RK Sharma, S Krishnan… - Frontiers in …, 2022 - frontiersin.org
Pregnant women constitute one of the most vulnerable populations to be affected by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the cause of coronavirus …

Intrauterine exposure to SARS-CoV-2 infection and early newborn brain development

N Andescavage, YC Lu, Y Wu, K Kapse, J Keller… - Cerebral …, 2024 - academic.oup.com
Epidemiologic studies suggest that prenatal exposures to certain viruses may influence
early neurodevelopment, predisposing offspring to neuropsychiatric conditions later in life …

SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants

CP Figueiredo, FL Fontes-Dantas, AT da Poian… - …, 2021 - Elsevier
A strong association between perinatal viral infections and neurodevelopmental disorders
has been established. Both the direct contact of the virus with the developing brain and the …

SARS-CoV-2 vaccination during pregnancy enhances hippocampal neurogenesis and working memory in offspring via IFN-gamma responsive microglia

F Qi, Z Yao - bioRxiv, 2024 - biorxiv.org
In the face of severe adverse outcomes of pandemic Coronavirus disease 2019 (COVID-19)
infection, vaccines proved potently immunogenic and safe in humans and are today strongly …

Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental outcomes

AC Brum, NE Vain - Seminars in Fetal and Neonatal Medicine, 2023 - Elsevier
After three years of the COVID-19 pandemic, we have learned many aspects of the disease
and the virus: its molecular structure, how it infects human cells, the clinical picture at …