International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

[HTML][HTML] Pharmacology of adenosine receptors: Recent advancements

F Vincenzi, S Pasquini, C Contri, M Cappello, M Nigro… - Biomolecules, 2023 - mdpi.com
Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Pharmacology of adenosine receptors: the state of the art

PA Borea, S Gessi, S Merighi… - Physiological …, 2018 - journals.physiology.org
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Adenosine receptors as therapeutic targets

KA Jacobson, ZG Gao - Nature reviews Drug discovery, 2006 - nature.com
Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

[HTML][HTML] Focusing on adenosine receptors as a potential targeted therapy in human diseases

WI Effendi, T Nagano, K Kobayashi, Y Nishimura - Cells, 2020 - mdpi.com
Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Adenosine receptors as potential therapeutic targets

SM Kaiser, RJ Quinn - Drug discovery today, 1999 - Elsevier
Recent studies indicate a widening role for adenosine receptors in many therapeutic areas.
Adenosine receptors are involved in immunological and inflammatory responses, respiratory …

Adenosine receptor targeting in health and disease

S Gessi, S Merighi, D Fazzi, A Stefanelli… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: The adenosine receptors A1, A2A, A2B and A3 are important and ubiquitous
mediators of cellular signaling that play vital roles in protecting tissues and organs from …

Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility

PG Baraldi, MA Tabrizi, S Gessi, PA Borea - Chemical reviews, 2008 - ACS Publications
The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—an update

BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2011 - ASPET
In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

Adenosine receptors as targets for drug development.

BB Fredholm - Drug news & perspectives, 2003 - europepmc.org
Adenosine is a ubiquitous autacoid that acts on four defined receptors, named A (1), A (2A),
A (2B) and A (3). Although the biological activity of adenosine has been known for more than …