Cancer cells maintain normal mitochondrial glutathione as one of the defense mechanisms
to inhibit mitochondrial membrane polarization and hence apoptosis. A combinational …

Effective targeting of mitochondria has emerged as an alternative strategy in cancer
chemotherapy. However, considering mitochondria's crucial role in cellular energetics …

Delivering traditional DNA-damaging anticancer drugs into mitochondria to damage
mitochondria is a promising chemotherapy strategy. The impermeability of this mitochondrial …

Highlights•Dysregulation of mitochondrial metabolism is a hallmark of cancer development.•
Nanoparticles (NPs) enable the efficient and targeted delivery of mitochondrial agents.•NPs …

Mitochondria are highly dynamic organelles involved in many cellular functions. Beyond
their central role in metabolism, they also take a part in maintaining calcium homeostasis …

Nearly a century has passed since Otto Warburg first observed high rates of aerobic
glycolysis in a variety of tumor cell types and suggested that this phenomenon might be due …

Cancer is an ever-increasing problem that is yet to be harnessed. Frequent mutations make
this pathology very variable and, consequently, a considerable challenge. Intriguingly …

Tumor resistance to chemotherapy is the major obstacle to employ cisplatin, one of the
broadly used chemotherapeutic drugs, for effective treatment of various tumors in the clinic …

The mitochondrion is a dynamic eukaryotic organelle that controls lethal and vital functions
of the cell. Being a critical center of metabolic activities and involved in many diseases …

Chemoresistant cells have acquired the ability to evade the action of multiple classes of anti-
neoplastic compounds. One mechanism by which tumor cells survive in the presence of …