Metal-chelating heteroaryl small molecules have found widespread use as building blocks
for coordination-driven, self-assembling nanostructures. The metal-chelating noncanonical …

We report a new computational protein design method for the construction of oligomeric
protein assemblies around metal centers with predefined coordination geometries. We apply …

Proteins are versatile natural building blocks with highly complex and multifunctional
architectures, and self-assembled protein structures have been created by the introduction …

The self-assembly of proteins into sophisticated multicomponent assemblies is a hallmark of
all living systems and has spawned extensive efforts in the construction of novel synthetic …

Genetically encoded unnatural amino acids could facilitate the design of proteins and
enzymes of novel function, but correctly specifying sites of incorporation and the identities …

Conspectus Nature puts to use only a small fraction of metal ions in the periodic table. Yet,
when incorporated into protein scaffolds, this limited set of metal ions carry out innumerable …

Proteins are nature's premier building blocks for constructing sophisticated nanoscale
architectures that carry out complex tasks and chemical transformations. Some 70%− 80% of …

Advances in protein chemistry and molecular and structural biology have empowered
modern chemists to build complex biological architectures using a “first principles” …

Owing to their central roles in cellular signaling, construction, and biochemistry, protein–
protein interactions (PPIs) and protein self-assembly have become a major focus of …

Proteins represent the most sophisticated building blocks available to an organism and to
the laboratory chemist. Yet, in contrast to nearly all other types of molecular building blocks …