Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor

G Papoff, P Hausler, A Eramo, MG Pagano… - Journal of Biological …, 1999 - ASBMB
The CD95 death receptor plays an important role in several physiological and pathological
apoptotic processes involving in particular the immune system. CD95 ligation leads to …

Pro-and anti-apoptotic CD95 signaling in T cells

M Paulsen, O Janssen - Cell Communication and Signaling, 2011 - Springer
The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the
prototypic death receptor in and outside the immune system. In fact, many mechanisms …

CD95 death‐inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells

A Eramo, M Sargiacomo, L Ricci‐Vitiani… - European journal of …, 2004 - Wiley Online Library
We investigated the membrane localization of CD95 in type I and type II cells, which differ in
their ability to recruit and activate caspase‐8. We found that CD95 was preferentially located …

Tissue-specific regulation of Fas/APO-1/CD95 expression by p53

P Lin, JA Bush, KJJ Cheung… - … journal of oncology, 2002 - spandidos-publications.com
The regulation of Fas/APO-1 (CD95), an important member of the tumor necrosis factor
(TNF) superfamily involved in membrane-mediated apoptosis, has been a subject of recent …

Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells

SS Mir, BWM Richter, CS Duckett - Blood, The Journal of the …, 2000 - ashpublications.org
CD30 is a member of the tumor necrosis factor (TNF) receptor superfamily that is expressed
on activated lymphocytes, as well as on neoplastic cells of Hodgkin disease (HD) and …

CD30 activates both the canonical and alternative NF-κB pathways in anaplastic large cell lymphoma cells

CW Wright, JM Rumble, CS Duckett - Journal of Biological Chemistry, 2007 - ASBMB
CD30 is a member of the tumor necrosis factor receptor superfamily whose expression is up-
regulated on anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma (HL) cells …

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

RM Siegel, F Ka-Ming Chan, HJ Chun… - Nature immunology, 2000 - nature.com
Originally identified as a cell surface receptor that triggered the death of lymphocytes and
tumor cells, it is now recognized that Fas (also known as CD95 or Apo-1) has distinct …

The CD95 (APO-1/Fas) DISC and beyond

ME Peter, PH Krammer - Cell Death & Differentiation, 2003 - nature.com
Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

Life in the Fas lane: differential outcomes of Fas signaling

E Brint, G O'Callaghan, A Houston - Cellular and Molecular Life Sciences, 2013 - Springer
Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth
factor superfamily. Although best characterized in terms of its apoptotic function, recent …

CD95 structure, aggregation and cell signaling

N Levoin, M Jean, P Legembre - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its
ligand CD95L brings to a next level its aggregation and triggers different signaling …