Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host
survival by down-regulating the inflammatory response or, alternatively, harmful by impairing …

Sepsis induces lymphocyte apoptosis and prevention of lymphocyte death may improve the
chances of surviving this disorder. We compared the efficacy of a selective caspase-3 …

The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …

Sepsis in mice possessing a functional human immune system causes extensive apoptotic
death of human immune effector cells and increases in both pro-and anti-inflammatory …

Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

In sepsis there is extensive apoptosis of lymphocytes, which may be beneficial by down-
regulating the accompanying inflammation. Alternatively, apoptosis may be detrimental by …

Patients with sepsis have impaired host defenses that contribute to the lethality of the
disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the …

Sepsis and multiple organ failure continue to be significant problems among trauma, burn,
and the critically ill patient population. Thus, a number of laboratories have focused on …