Significance: Many reports have underscored the importance of the heme degradation
pathway that is regulated by heme oxygenase (HO). This reaction releases bile pigments …

Abstract Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative
degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in …

Abstract Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide
(CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the …

Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by
production of biliverdin, free iron and carbon monoxide (CO). There are three isoforms of …

Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme, converting
heme to biliverdin, during which iron is released and carbon monoxide (CO) is emitted; …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …

抄録 Hemorrhagic shock causes oxidative stress that leads to tissue injuries in various
organs including the lung, liver, kidney and intestine. Excess amounts of free heme released …

The heme-heme oxygenase system has recently been recognized to possess important
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …

ABSTRACT Heme oxygenase‐1 (HO‐1), which degrades heme into three products (carbon
monoxide, free iron, and biliverdin), plays a protective role in many models of disease via its …