There is increasing evidence that DNA methylation is a critical source of gene regulation. In
addition, interindividual differences in DNA methylation status in cancer related genes are …

Large‑scale projects, such as The Cancer Genome Atlas (TCGA), Human Epigenome
Project (HEP) and Human Epigenome Atlas (HEA), provide an insight into DNA methylation …

BACKGROUND DNA hypermethylation has emerged as a novel molecular biomarker for the
evaluation of prostate cancer diagnosis and prognosis. Defining the specific gene …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

DNA methylation is one of the most important epigenetic mechanisms in regulating gene
expression. Genome hypermethylation has been proposed as a critical mechanism in …

Promoter hypermethylation is associated with the loss of expression of tumor-suppressor
genes in cancer. Currently, several genome-wide technologies are available and have been …

Background Promoter and 5′ end methylation regulation of tumour suppressor genes is a
common feature of many cancers. Such occurrences often lead to the silencing of these key …

Background Aberrant DNA methylation may promote prostate carcinogenesis. We
investigated epigenome‐wide DNA methylation profiles in prostate cancer (PCa) compared …

Simple Summary Prostate cancer is a major cause of cancer-related death in men
worldwide. There is an urgent clinical need for improved prognostic biomarkers to better …